Although vaccines are considered safe by the AAP and CDC, there is a possibility of side effects. Of those children who do experience side effects, most have only minor symptoms, such as a low-grade fever or soreness at the site of the injection. Other temporary symptoms may include joint pain, headaches, nausea, cough, diarrhea and upper respiratory infections. The risk of serious or severe side effects is very low but you should discuss them with your child’s pediatrician prior to getting vaccines.